Assay Detail
Binding
CHEMBL1040228
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Inhibition of NF-kappaB activation
92
Total Activities
92
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The first pharmacophore model for potent NF-kappaB inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 92 | 6.22 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566561 | — | — | 1 | 8.70 |
| CHEMBL567020 | — | — | 1 | 8.40 |
| CHEMBL579032 | — | — | 1 | 7.96 |
| CHEMBL522502 | — | — | 1 | 7.96 |
| CHEMBL566185 | — | — | 1 | 7.92 |
| CHEMBL567456 | — | — | 1 | 7.92 |
| CHEMBL569503 | — | — | 1 | 7.85 |
| CHEMBL566186 | — | — | 1 | 7.70 |
| CHEMBL566146 | — | — | 1 | 7.68 |
| CHEMBL584470 | — | — | 1 | 7.42 |
| CHEMBL565346 | — | — | 1 | 7.40 |
| CHEMBL566358 | — | — | 1 | 7.40 |
| CHEMBL583207 | DIDESMETHYLROCAGLAMIDE | — | 1 | 7.36 |
| CHEMBL568992 | — | — | 1 | 7.05 |
| CHEMBL571909 | — | — | 1 | 7.03 |
| CHEMBL566589 | — | — | 1 | 6.81 |
| CHEMBL152971 | — | — | 1 | 6.75 |
| CHEMBL583849 | — | — | 1 | 6.71 |
| CHEMBL569777 | — | — | 1 | 6.68 |
| CHEMBL566395 | — | — | 1 | 6.68 |
| CHEMBL566590 | — | — | 1 | 6.68 |
| CHEMBL571681 | — | — | 1 | 6.61 |
| CHEMBL579038 | — | — | 1 | 6.59 |
| CHEMBL571921 | — | — | 1 | 6.51 |
| CHEMBL149553 | — | — | 1 | 6.50 |
| CHEMBL582805 | — | — | 1 | 6.50 |
| CHEMBL149800 | — | — | 1 | 6.46 |
| CHEMBL567665 | — | — | 1 | 6.41 |
| CHEMBL249211 | — | — | 1 | 6.37 |
| CHEMBL572137 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566561 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL567020 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL522502 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL579032 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL566185 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL567456 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL569503 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL566186 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL566146 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL584470 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL565346 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL566358 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL583207 | DIDESMETHYLROCAGLAMIDE | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL568992 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL571909 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL566589 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL152971 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL583849 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL569777 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL566395 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL566590 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL571681 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL579038 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL571921 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL582805 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL149553 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL149800 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL567665 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL249211 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL572137 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL468454 | ROCAGLAOL | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL313952 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL567666 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL271669 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL153483 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL566394 | — | IC50 | = | 685.0 | nM | 6.16 |
| CHEMBL64925 | MG-132 | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL434503 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL153733 | — | IC50 | = | 851.0 | nM | 6.07 |
| CHEMBL273149 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL402638 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL256061 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL428064 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL271233 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL272552 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL256403 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL404128 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL401504 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL269941 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL429599 | — | IC50 | = | 1100.0 | nM | 5.96 |