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Compound Detail

CHEMBL272234

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O=C(O)c1ccc(Oc2ccc(CCNC[C@H](O)c3cccc(Cl)c3)cc2)nc1

Basic Information

ChEMBL ID CHEMBL272234
Phase Preclinical
Structure Type MOL
InChI Key NJVIQYGVTISQPV-FQEVSTJZSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

412.9
MW (Da)
4.09
ALogP
5
HBA
3
HBD
91.7
PSA (Ų)
0.46
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H21ClN2O4
MW 412.87
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -1.10

Activity Summary

EC50 2 meas. best 8.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL213
EC50 8.85 8.85 1.4 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.06 8.06 8.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18307290 10.1021/jm701324c Beta-3 adrenergic receptor 2
18307290 10.1021/jm701324c Canis familiaris 2
18307290 10.1021/jm701324c Beta-1 adrenergic receptor 1
18307290 10.1021/jm701324c Unchecked 1

Data from ChEMBL 36 via Core Engine