Compound Detail
CHEMBL274010
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL274010 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UUIUKURBZCYZSJ-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
316.4
MW (Da)
3.06
ALogP
5
HBA
0
HBD
55.5
PSA (Ų)
0.77
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL4153 | Ki | 8.07 | 8.07 | 8.5 | 1 |
| Unchecked CHEMBL612545 | Ki | 8.07 | 7.185 | 8.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 8.5 | nM | 8.07 | Displacement of [3H]DTG from sigma 2 receptor in rat liver membrane | 18440098 |
| Sigma non-opioid intracellular receptor 1 | Ki | = | 8.5 | nM | 8.07 | Displacement of [3H](+)pentazocine from sigma-1 receptor in Cavia porcellus (gui... | - |
| Unchecked | Ki | = | 496.0 | nM | 6.3 | Displacement of [3H]DTG from sigma-1 receptor in Cavia porcellus (guinea pig) br... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9544213 | 10.1021/jm970682+ | Mus musculus | 4 |
| 9544213 | 10.1021/jm970682+ | ADMET | 2 |
| 18440098 | 10.1016/j.ejmech.2008.03.011 | Unchecked | 2 |
| - | 10.1007/s00044-005-0131-1 | Unchecked | 2 |
| - | 10.1007/s00044-005-0131-1 | Sigma non-opioid intracellular receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine