Compound Detail
CHEMBL274906
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL274906 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QNIOUMVBOGKRQV-VAWYXSNFSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
326.4
MW (Da)
3.14
ALogP
4
HBA
2
HBD
71.3
PSA (Ų)
0.26
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone deacetylase HD2 CHEMBL4919 | IC50 | 6.96 | 6.96 | 109.7 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone deacetylase HD2 | IC50 | = | 110.0 | nM | 6.96 | Concentration required for inhibition of histone deacetylase HD2 in vitro. | 14971890 |
| Histone deacetylase HD2 | IC50 | = | 109.65 | nM | 6.96 | Inhibitory concentration against histone deacetylase HD2 enzyme. | 14971890 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14971890 | 10.1021/jm030990+ | Histone deacetylase HD2 | 3 |
Data from ChEMBL 36 via Core Engine