Assay Detail
Binding
CHEMBL695147
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Concentration required for inhibition of histone deacetylase HD2 in vitro.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zea mays |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.20 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.14 |
| CHEMBL274445 | TRAPOXIN A | — | 1 | 8.00 |
| CHEMBL268286 | — | — | 1 | 7.37 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.30 |
| CHEMBL13200 | — | — | 1 | 7.15 |
| CHEMBL12760 | — | — | 1 | 7.00 |
| CHEMBL12927 | — | — | 1 | 7.00 |
| CHEMBL274906 | — | — | 1 | 6.96 |
| CHEMBL279636 | — | — | 1 | 6.96 |
| CHEMBL273731 | — | — | 1 | 6.94 |
| CHEMBL265077 | — | — | 1 | 6.89 |
| CHEMBL12890 | — | — | 1 | 6.84 |
| CHEMBL269230 | — | — | 1 | 6.70 |
| CHEMBL273454 | — | — | 1 | 6.68 |
| CHEMBL13152 | — | — | 1 | 6.58 |
| CHEMBL276707 | — | — | 1 | 6.51 |
| CHEMBL275037 | — | — | 1 | 6.11 |
| CHEMBL411020 | — | — | 1 | 6.00 |
| CHEMBL275089 | — | — | 1 | 5.92 |
| CHEMBL267781 | — | — | 1 | 5.89 |
| CHEMBL13000 | — | — | 1 | 5.85 |
| CHEMBL13196 | — | — | 1 | 5.83 |
| CHEMBL268245 | — | — | 1 | 5.57 |
| CHEMBL13168 | — | — | 1 | 5.42 |
| CHEMBL268716 | — | — | 1 | 5.00 |
| CHEMBL267309 | — | — | 1 | 4.97 |
| CHEMBL422390 | — | — | 1 | 4.77 |
| CHEMBL268977 | — | — | 1 | 4.69 |
| CHEMBL12986 | — | — | 1 | 4.46 |
| CHEMBL13235 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL274445 | TRAPOXIN A | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL268286 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL13200 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL12760 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL12927 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL274906 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL279636 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL273731 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL265077 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL12890 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL269230 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL273454 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL13152 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL276707 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL275037 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL411020 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL275089 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL267781 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL13000 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL13196 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL268245 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL13168 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL268716 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL267309 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL422390 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL268977 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL12986 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL13235 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL12983 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL433 | VALPROATE SODIUM | IC50 | = | 128000.0 | nM | - |