Compound Detail
CHEMBL276707
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Basic Information
| ChEMBL ID | CHEMBL276707 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RLJXQVYXDDGCDN-BQYQJAHWSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
310.4
MW (Da)
2.53
ALogP
4
HBA
2
HBD
71.3
PSA (Ų)
0.39
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone deacetylase HD2 CHEMBL4919 | IC50 | 6.51 | 6.51 | 309.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone deacetylase HD2 | IC50 | = | 310.0 | nM | 6.51 | Concentration required for inhibition of histone deacetylase HD2 in vitro. | 14971890 |
| Histone deacetylase HD2 | IC50 | = | 309.03 | nM | 6.51 | Inhibitory concentration against histone deacetylase HD2 enzyme. | 14971890 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14971890 | 10.1021/jm030990+ | Histone deacetylase HD2 | 3 |
Data from ChEMBL 36 via Core Engine