Compound Detail
CHEMBL276798
GR-175737 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL276798 |
| Name | GR-175737 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CPOUJACQGWJJQB-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
288.7
MW (Da)
2.82
ALogP
4
HBA
1
HBD
67.6
PSA (Ų)
0.78
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL4124 | Ki | 8.6 | 8.3167 | 2.5 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 2.5 | nM | 8.6 | Displacement of [3H](R)-alpha-methylhistamine from histamine H3 receptor in rat ... | 29960729 |
| Histamine H3 receptor | Ki | = | 6.31 | nM | 8.2 | Binding affinity against H3 receptor in rat cerebral cortex membranes was evalua... | - |
| Histamine H3 receptor | Ki | = | 7.0 | nM | 8.15 | Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor | 9871722 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(96)00122-9 | Rattus norvegicus | 4 |
| - | 10.1016/0960-894X(96)00122-9 | Histamine H3 receptor | 2 |
| 9871722 | 10.1016/s0960-894x(98)00181-4 | Histamine H3 receptor | 1 |
| - | 10.1016/0960-894X(96)00122-9 | Histamine H2 receptor | 1 |
| - | 10.1016/0960-894X(96)00122-9 | Histamine H1 receptor | 1 |
| 29960729 | 10.1016/j.bmc.2018.06.028 | Histamine H3 receptor | 1 |
Data from ChEMBL 36 via Core Engine