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Compound Detail

CHEMBL279782

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CN1CCC(=O)N(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1=O

Basic Information

ChEMBL ID CHEMBL279782
Phase Preclinical
Structure Type MOL
InChI Key PNHWVHVANRGXBE-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
2
Publications
0
Known Names

Molecular Properties

573.6
MW (Da)
3.09
ALogP
7
HBA
1
HBD
132.7
PSA (Ų)
0.48
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H31N5O7
MW 573.61
Aromatic Rings 3
Heavy Atoms 42
NP-Likeness -1.03

Activity Summary

Ki 1 meas. best 8.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Oxytocin receptor
CHEMBL2049
Ki 8.4 8.4 4.0 1

Pharmacokinetic Data

Parameter Value Units Species
CL 27.0 mL.min-1.kg-1 Canis lupus familiaris

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Oxytocin receptor Ki = 3.981 nM 8.4 Ability to displace [3H]oxytocin from human OT receptor (hOT) 11992786

Literature References

PubMed DOI Target Context # Activities
11992786 10.1016/s0960-894x(02)00159-2 Oxytocin receptor 1
11992786 10.1016/s0960-894x(02)00159-2 Canis familiaris 1

Data from ChEMBL 36 via Core Engine