Compound Detail
CHEMBL281273
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Basic Information
| ChEMBL ID | CHEMBL281273 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WJRKPLARAFQQGZ-GOSISDBHSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
343.4
MW (Da)
4.52
ALogP
3
HBA
2
HBD
43.7
PSA (Ų)
0.68
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 CHEMBL3223 | Ki | 7.44 | 7.44 | 36.2 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 6.86 | 6.86 | 139.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | Ki | = | 36.2 | nM | 7.44 | Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CH... | 11311055 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 139.0 | nM | 6.86 | Displacement of [3H]8-OH-DPAT from human 5-hydroxytryptamine 1A receptor express... | 11311055 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11311055 | 10.1021/jm0108505 | 5-hydroxytryptamine receptor 7 | 2 |
| 11311055 | 10.1021/jm0108505 | 5-hydroxytryptamine receptor 1A | 1 |
| 11311055 | 10.1021/jm0108505 | D(2) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine