Compound Detail
CHEMBL281378
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CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(-c4nn[nH]n4)ccc23)cc1
Basic Information
| ChEMBL ID | CHEMBL281378 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YZWRJRVDHDWEOE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
558.6
MW (Da)
3.85
ALogP
9
HBA
2
HBD
141.1
PSA (Ų)
0.31
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin-1 receptor CHEMBL252 | IC50 | 7.46 | 7.46 | 35.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | IC50 | = | 35.0 | nM | 7.46 | Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) recepto... | 11755336 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11755336 | 10.1016/s0960-894x(01)00660-6 | Endothelin-1 receptor | 1 |
| 11755336 | 10.1016/s0960-894x(01)00660-6 | Endothelin receptor type B | 1 |
Data from ChEMBL 36 via Core Engine