Compound Detail
CHEMBL281622
CP-339818 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL281622 |
| Name | CP-339818 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MMGAVKCAGQCFHS-LSDHQDQOSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
304.4
MW (Da)
4.78
ALogP
2
HBA
0
HBD
17.3
PSA (Ų)
0.58
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 CHEMBL4633 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| Potassium voltage-gated channel subfamily A member 3 CHEMBL4818 | IC50 | 6.64 | 6.64 | 230.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 | IC50 | = | 200.0 | nM | 6.7 | Displacement of [125I]- ChTX from human T cell voltage-gated potassium channel s... | 10612582 |
| Potassium voltage-gated channel subfamily A member 3 | IC50 | = | 230.0 | nM | 6.64 | Blockade of peak steady-state K+ currents of voltage-gated potassium channel sub... | 11312924 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 10612582 | 10.1016/s0960-894x(99)00601-0 | Potassium voltage-gated channel subfamily A member 3 | 1 |
| 11312924 | 10.1021/jm001007u | Potassium voltage-gated channel subfamily A member 3 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine