Compound Detail
CHEMBL28333
MEDAZEPAM 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL28333 |
| Name | MEDAZEPAM |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | YLCXGBZIZBEVPZ-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
3
Known Names
1
Indications
Molecular Properties
270.8
MW (Da)
3.63
ALogP
2
HBA
0
HBD
15.6
PSA (Ų)
0.77
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Anxiety
ATC Classification
N05BA03
medazepam
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOLEPTICS
Activity Summary
Ki 1 meas. best 6.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL1907607 | Ki | 6.28 | 6.28 | 528.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ki | = | 528.0 | nM | 6.28 | In vitro binding affinity against benzodiazepine receptor using [3H]diazepam as ... | 2993620 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 490555 | 10.1021/jm00195a016 | Mus musculus | 7 |
| 7359533 | 10.1021/jm00176a016 | Rattus norvegicus | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Nuclear receptor subfamily 1 group I member 2 | 3 |
| 2993620 | 10.1021/jm00147a034 | GABA-A receptor; anion channel | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2B | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Androgen receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2A | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Cannabinoid receptor 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-1 adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-2 adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 1A | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Gamma-aminobutyric acid receptor subunit alpha-1 | 2 |
| 7359533 | 10.1021/jm00176a016 | No relevant target | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent dopamine transporter | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Glutamate receptor ionotropic, NMDA 1 | 1 |
| - | 10.1007/s00044-012-9977-1 | Whole blood | 1 |
| 17574307 | 10.1016/j.ejmech.2007.04.009 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine