Compound Detail
CHEMBL28517
E927A Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL28517 |
| Name | E927A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XOZUGNYVDXMRKW-AATRIKPKSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
116.1
MW (Da)
-0.40
ALogP
2
HBA
2
HBD
110.9
PSA (Ų)
0.42
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.3
EC50 1 meas. best 4.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EHMT2 CHEMBL6032 | IC50 | 6.3 | 6.3 | 500.0 | 1 |
| Histone-lysine N-methyltransferase EHMT1 CHEMBL6031 | IC50 | 5.77 | 5.77 | 1700.0 | 1 |
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 4.42 | 4.42 | 38000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EHMT2 | IC50 | = | 500.0 | nM | 6.3 | Inhibition of wild type recombinant human histone lysine methyltransferase G9a (... | 29519735 |
| Histone-lysine N-methyltransferase EHMT1 | IC50 | = | 1700.0 | nM | 5.77 | Inhibition of wild type recombinant human histone lysine methyltransferase GLP (... | 29519735 |
| Human immunodeficiency virus 1 | EC50 | = | 38000.0 | nM | 4.42 | Compound concentration that provides 50% cytoprotection on CEM-SS cells and HIV-... | 9554870 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29519735 | 10.1016/j.bmcl.2018.02.043 | Histone-lysine N-methyltransferase EHMT1 | 4 |
| 29519735 | 10.1016/j.bmcl.2018.02.043 | Histone-lysine N-methyltransferase EHMT2 | 4 |
| 9554870 | 10.1021/jm9708543 | Human immunodeficiency virus 1 | 2 |
| 9554870 | 10.1021/jm9708543 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine