Compound Detail
CHEMBL286252
NAFADOTRIDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL286252 |
| Name | NAFADOTRIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IDZASIQMRGPBCQ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
365.5
MW (Da)
3.71
ALogP
4
HBA
1
HBD
65.4
PSA (Ų)
0.81
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(3) dopamine receptor CHEMBL234 | Ki | 9.96 | 9.525 | 0.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor | Ki | = | 0.11 | nM | 9.96 | Binding affinity against Dopamine receptor D3 | 14998318 |
| D(3) dopamine receptor | Ki | = | 0.81 | nM | 9.09 | Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in... | 14521403 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 14998318 | 10.1021/jm030480f | Dopamine receptors; D2 & D3 | 1 |
| 14998318 | 10.1021/jm030480f | D(3) dopamine receptor | 1 |
| 14521403 | 10.1021/jm030085p | D(3) dopamine receptor | 1 |
| 9873609 | 10.1016/s0960-894x(98)00469-7 | D(2) dopamine receptor | 1 |
| - | 10.6019/CHEMBL4513141 | Candida albicans | 1 |
| - | 10.6019/CHEMBL4513141 | Cryptococcus neoformans | 1 |
| - | 10.6019/CHEMBL4513141 | Escherichia coli | 1 |
| - | 10.6019/CHEMBL4513141 | Klebsiella pneumoniae | 1 |
| - | 10.6019/CHEMBL4513141 | Pseudomonas aeruginosa | 1 |
| - | 10.6019/CHEMBL4513141 | Acinetobacter baumannii | 1 |
| - | 10.6019/CHEMBL4513141 | Staphylococcus aureus | 1 |
Data from ChEMBL 36 via Core Engine