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Compound Detail

CHEMBL286895

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O=C(Cn1ccc(N2CCOCC2)nc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1

Basic Information

ChEMBL ID CHEMBL286895
Phase Preclinical
Structure Type MOL
InChI Key TYMAGDHTHBFHTQ-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
6
PK Parameters
3
Publications
0
Known Names

Molecular Properties

626.7
MW (Da)
2.90
ALogP
10
HBA
1
HBD
139.4
PSA (Ų)
0.33
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H34N6O7
MW 626.67
Aromatic Rings 4
Heavy Atoms 46
NP-Likeness -1.31

Activity Summary

Ki 1 meas. best 9.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Oxytocin receptor
CHEMBL2049
Ki 9.3 9.3 0.5 1

Pharmacokinetic Data

Parameter Value Units Species
CL 17.0 mL.min-1.kg-1 Rattus norvegicus
CL 11.0 mL.min-1.kg-1 Canis lupus familiaris
F 1.0 % Rattus norvegicus
F 2.0 % Canis lupus familiaris
T1/2 0.8 hr Rattus norvegicus
T1/2 1.2 hr Canis lupus familiaris

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Oxytocin receptor Ki = 0.5012 nM 9.3 Displacement of 3[H]oxytocin from human oxytocin receptor 11992787

Literature References

PubMed DOI Target Context # Activities
11992787 10.1016/s0960-894x(02)00160-9 Rattus norvegicus 3
11992787 10.1016/s0960-894x(02)00160-9 Canis familiaris 3
11992787 10.1016/s0960-894x(02)00160-9 Oxytocin receptor 1

Data from ChEMBL 36 via Core Engine