Compound Detail
CHEMBL295487
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NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2CC(c3ccc4c(c3Cl)OCO4)=NO2)cc1
Basic Information
| ChEMBL ID | CHEMBL295487 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VZRXQEBFEMILLZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
499.9
MW (Da)
3.51
ALogP
7
HBA
2
HBD
129.3
PSA (Ų)
0.55
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Coagulation factor X CHEMBL244 | Ki | 5.77 | 5.77 | 1700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Coagulation factor X | Ki | = | 1700.0 | nM | 5.77 | Binding affinity against the Factor Xa (FXa) | 12729667 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12729667 | 10.1016/s0960-894x(03)00130-6 | Coagulation factor X | 1 |
Data from ChEMBL 36 via Core Engine