Compound Detail
CHEMBL304614
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Basic Information
| ChEMBL ID | CHEMBL304614 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KTPHQXMERWMSHG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
448.0
MW (Da)
5.92
ALogP
4
HBA
1
HBD
68.0
PSA (Ų)
0.38
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin II receptor (AT-1) type-1 CHEMBL2094250 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin II receptor (AT-1) type-1 | IC50 | = | 200.0 | nM | 6.7 | Inhibitory concentration was evaluated by measuring displacement of [3H]AII from... | 8667363 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8667363 | 10.1021/jm9508853 | Angiotensin II receptor (AT-1) type-1 | 1 |
| 8667363 | 10.1021/jm9508853 | Angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine