Compound Detail
CHEMBL305406
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Basic Information
| ChEMBL ID | CHEMBL305406 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | STCVFKBRXOEQRF-YBEGLDIGSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
14
Publications
0
Known Names
Molecular Properties
352.3
MW (Da)
5.28
ALogP
4
HBA
0
HBD
39.9
PSA (Ų)
0.56
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.96
Ki 1 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL2851 | IC50 | 6.96 | 6.63 | 110.0 | 2 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | Ki | 6.96 | 6.96 | 110.0 | 1 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | IC50 | 6.27 | 6.27 | 533.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | IC50 | = | 110.0 | nM | 6.96 | Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 e... | 10465539 |
| Metabotropic glutamate receptor 2 | Ki | = | 110.0 | nM | 6.96 | Antagonist potency against cloned Metabotropic glutamate receptor 2 | 10893301 |
| Metabotropic glutamate receptor 2 | IC50 | = | 500.0 | nM | 6.3 | Inhibition of [3H]-DCG IV binding on rat mGluR2 transfected cell membranes from ... | 10465539 |
| Metabotropic glutamate receptor 2 | IC50 | = | 533.0 | nM | 6.27 | Non-competitive antagonist activity at human recombinant mGluR2 expressed in Che... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10465539 | 10.1016/s0960-894x(99)00346-7 | Metabotropic glutamate receptor 2 | 2 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 1 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 2 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 3 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 4 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 5 | 1 |
| 10465539 | 10.1016/s0960-894x(99)00346-7 | Glutamate receptor ionotropic, AMPA | 1 |
| 10465539 | 10.1016/s0960-894x(99)00346-7 | Glutamate receptor ionotropic, kainate | 1 |
| 10465539 | 10.1016/s0960-894x(99)00346-7 | Glutamate receptor ionotropic, NMDA 2C | 1 |
| 10465539 | 10.1016/s0960-894x(99)00346-7 | Metabotropic glutamate receptor 4 | 1 |
| 10465539 | 10.1016/s0960-894x(99)00346-7 | Metabotropic glutamate receptor 1 | 1 |
| 10465539 | 10.1016/s0960-894x(99)00346-7 | Metabotropic glutamate receptor 5 | 1 |
| - | 10.1039/C3MD00110E | Metabotropic glutamate receptor 2 | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine