Compound Detail
CHEMBL305799
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Basic Information
| ChEMBL ID | CHEMBL305799 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HVOGTXUMRHCNEQ-NVNXTCNLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
324.2
MW (Da)
4.50
ALogP
4
HBA
0
HBD
39.9
PSA (Ų)
0.78
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL2851 | IC50 | 5.59 | 5.59 | 2550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | IC50 | = | 2550.0 | nM | 5.59 | Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 e... | 10465539 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10465539 | 10.1016/s0960-894x(99)00346-7 | Metabotropic glutamate receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine