Compound Detail
CHEMBL305885
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Basic Information
| ChEMBL ID | CHEMBL305885 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UEQWCLVERDRYPK-OXJNMPFZSA-N |
1
Targets
8
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
352.4
MW (Da)
3.87
ALogP
3
HBA
2
HBD
66.8
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 8 meas. best 7.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leukotriene B4 receptor CHEMBL2095160 | IC50 | 7.11 | 6.4713 | 78.0 | 8 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Leukotriene B4 receptor | IC50 | = | 78.0 | nM | 7.11 | Inhibition of LTB4 receptor induced chemotaxis of isolated human neutrophils | - |
| Leukotriene B4 receptor | IC50 | = | 98.0 | nM | 7.01 | Inhibition of LTB4 receptor induced chemotaxis of isolated human neutrophils | - |
| Leukotriene B4 receptor | IC50 | = | 160.0 | nM | 6.8 | Inhibition of LTB4 receptor induced chemotaxis of isolated human neutrophils | - |
| Leukotriene B4 receptor | IC50 | = | 290.0 | nM | 6.54 | Inhibition of leukotriene B4 (LTB4) binding to guinea pig spleen | - |
| Leukotriene B4 receptor | IC50 | = | 320.0 | nM | 6.5 | Inhibition of leukotriene B4 (LTB4) binding to guinea pig spleen | - |
| Leukotriene B4 receptor | IC50 | = | 420.0 | nM | 6.38 | Inhibition of leukotriene B4 (LTB4) binding to guinea pig spleen | - |
| Leukotriene B4 receptor | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of LTB4 receptor induced chemotaxis of isolated human neutrophils | - |
| Leukotriene B4 receptor | IC50 | = | 3400.0 | nM | 5.47 | Inhibition of leukotriene B4 (LTB4) binding to guinea pig spleen | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00414-9 | Leukotriene B4 receptor | 8 |
| - | 10.1016/S0960-894X(97)00414-9 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine