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Assay Detail

CHEMBL704371

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of leukotriene B4 (LTB4) binding to guinea pig spleen
ChEMBL ↗
47
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Spleen
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Leukotriene B4 receptor (CHEMBL2095160) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor
Reiter LA, Melvin LS, Crean GL, Showell HJ, Koch K, Biggers MS, Cheng JB, Breslow R, Conklyn MJ, Farrell CA, Hada WA, Laird ER, Martin JJ, Todd Miller G, Pillar JS
Bioorg Med Chem Lett (1997) 7 : 2307 -2312
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 47 5.63 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL51770 — — 3 8.49
CHEMBL309795 — — 3 6.70
CHEMBL305885 — — 4 6.54
CHEMBL306075 — — 1 6.54
CHEMBL75186 — — 1 6.46
CHEMBL76020 — — 1 6.31
CHEMBL420019 — — 1 6.25
CHEMBL76235 — — 1 6.19
CHEMBL73855 — — 1 6.17
CHEMBL74728 — — 4 5.92
CHEMBL75243 — — 1 5.70
CHEMBL78039 — — 1 5.57
CHEMBL76453 — — 1 5.57
CHEMBL74953 — — 1 5.50
CHEMBL306513 — — 1 5.44
CHEMBL74717 — — 1 5.40
CHEMBL307288 — — 1 5.27
CHEMBL307662 — — 1 5.22
CHEMBL74488 — — 1 5.10
CHEMBL306138 — — 1 5.10
CHEMBL76006 — — 1 5.06
CHEMBL75366 — — 1 4.92
CHEMBL74602 — — 1 4.92
CHEMBL308861 — — 1 4.92
CHEMBL306548 — — 1 4.89
CHEMBL306357 — — 1 4.77
CHEMBL306058 — — 1 4.70
CHEMBL74910 — — 2 4.60
CHEMBL74412 — — 1 4.47
CHEMBL75421 — — 1 4.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL51770 — IC50 = 3.2 nM 8.49
CHEMBL51770 — IC50 = 5.6 nM 8.25
CHEMBL51770 — IC50 = 6.4 nM 8.19
CHEMBL309795 — IC50 = 200.0 nM 6.70
CHEMBL309795 — IC50 = 240.0 nM 6.62
CHEMBL309795 — IC50 = 250.0 nM 6.60
CHEMBL305885 — IC50 = 290.0 nM 6.54
CHEMBL306075 — IC50 = 290.0 nM 6.54
CHEMBL305885 — IC50 = 320.0 nM 6.50
CHEMBL75186 — IC50 = 350.0 nM 6.46
CHEMBL305885 — IC50 = 420.0 nM 6.38
CHEMBL76020 — IC50 = 490.0 nM 6.31
CHEMBL420019 — IC50 = 560.0 nM 6.25
CHEMBL76235 — IC50 = 650.0 nM 6.19
CHEMBL73855 — IC50 = 680.0 nM 6.17
CHEMBL74728 — IC50 = 1200.0 nM 5.92
CHEMBL74728 — IC50 = 1300.0 nM 5.89
CHEMBL75243 — IC50 = 2000.0 nM 5.70
CHEMBL74728 — IC50 = 2300.0 nM 5.64
CHEMBL78039 — IC50 = 2700.0 nM 5.57
CHEMBL76453 — IC50 = 2700.0 nM 5.57
CHEMBL74953 — IC50 = 3200.0 nM 5.50
CHEMBL305885 — IC50 = 3400.0 nM 5.47
CHEMBL306513 — IC50 = 3600.0 nM 5.44
CHEMBL74717 — IC50 = 4000.0 nM 5.40
CHEMBL307288 — IC50 = 5400.0 nM 5.27
CHEMBL307662 — IC50 = 6000.0 nM 5.22
CHEMBL74488 — IC50 = 8000.0 nM 5.10
CHEMBL306138 — IC50 = 8000.0 nM 5.10
CHEMBL76006 — IC50 = 8800.0 nM 5.06
CHEMBL74602 — IC50 = 12000.0 nM 4.92
CHEMBL308861 — IC50 = 12000.0 nM 4.92
CHEMBL75366 — IC50 = 12000.0 nM 4.92
CHEMBL306548 — IC50 = 13000.0 nM 4.89
CHEMBL306357 — IC50 = 17000.0 nM 4.77
CHEMBL306058 — IC50 = 20000.0 nM 4.70
CHEMBL74910 — IC50 = 25000.0 nM 4.60
CHEMBL74910 — IC50 = 30000.0 nM 4.52
CHEMBL74412 — IC50 = 34000.0 nM 4.47
CHEMBL75421 — IC50 = 40000.0 nM 4.40
CHEMBL74728 — IC50 = 40000.0 nM 4.40
CHEMBL74202 — IC50 = 53000.0 nM 4.28
CHEMBL311850 — IC50 = 100000.0 nM 4.00
CHEMBL74806 — IC50 = 100000.0 nM 4.00
CHEMBL311406 — IC50 > 100000.0 nM -
CHEMBL307287 — IC50 > 100000.0 nM -
CHEMBL74099 — IC50 > 100000.0 nM -