Compound Detail
CHEMBL309795
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL309795 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GRWJJQZOORCENE-LAUBAEHRSA-N |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
366.5
MW (Da)
4.26
ALogP
3
HBA
2
HBD
66.8
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 6.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leukotriene B4 receptor CHEMBL2095160 | IC50 | 6.77 | 6.625 | 170.0 | 6 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Leukotriene B4 receptor | IC50 | = | 170.0 | nM | 6.77 | Inhibition of LTB4 receptor induced chemotaxis of isolated human neutrophils | - |
| Leukotriene B4 receptor | IC50 | = | 200.0 | nM | 6.7 | Inhibition of leukotriene B4 (LTB4) binding to guinea pig spleen | - |
| Leukotriene B4 receptor | IC50 | = | 230.0 | nM | 6.64 | Inhibition of LTB4 receptor induced chemotaxis of isolated human neutrophils | - |
| Leukotriene B4 receptor | IC50 | = | 240.0 | nM | 6.62 | Inhibition of leukotriene B4 (LTB4) binding to guinea pig spleen | - |
| Leukotriene B4 receptor | IC50 | = | 250.0 | nM | 6.6 | Inhibition of leukotriene B4 (LTB4) binding to guinea pig spleen | - |
| Leukotriene B4 receptor | IC50 | = | 380.0 | nM | 6.42 | Inhibition of LTB4 receptor induced chemotaxis of isolated human neutrophils | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00414-9 | Leukotriene B4 receptor | 6 |
Data from ChEMBL 36 via Core Engine