Compound Detail
CHEMBL3086851
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)C(NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)(C)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C(C)C
Basic Information
| ChEMBL ID | CHEMBL3086851 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KAOYDGWFNVQWFV-GPACABEUSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
3311.7
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.77
IC50 1 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor CHEMBL1784 | EC50 | 9.77 | 9.77 | 0.2 | 1 |
| Glucagon-like peptide 1 receptor CHEMBL1784 | IC50 | 8.12 | 8.12 | 7.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucagon-like peptide 1 receptor | EC50 | = | 0.17 | nM | 9.77 | Agonist activity at human GLP-1R expressed in African green monkey COS7 cells as... | 24044354 |
| Glucagon-like peptide 1 receptor | IC50 | = | 7.6 | nM | 8.12 | Displacement of [125I]-exendin (9 to 39) from human GLP-1R expressed in African ... | 24044354 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24044354 | 10.1021/jm400423p | Mus musculus | 17 |
| 24044354 | 10.1021/jm400423p | Glucagon-like peptide 1 receptor | 2 |
| 24044354 | 10.1021/jm400423p | Dipeptidyl peptidase 4 | 1 |
Data from ChEMBL 36 via Core Engine