Assay Detail
Functional
CHEMBL3090286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GLP-1R expressed in African green monkey COS7 cells assessed as stimulation of cAMP production
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A general method for making peptide therapeutics resistant to serine protease degradation: application to dipeptidyl peptidase IV substrates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 3 | - | - |
| EC50 | 3 | 9.61 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3086851 | — | — | 1 | 9.77 |
| CHEMBL3086852 | — | — | 1 | 9.59 |
| CHEMBL410972 | — | — | 1 | 9.46 |
| CHEMBL3086848 | — | — | 1 | - |
| CHEMBL3086849 | — | — | 1 | - |
| CHEMBL2401865 | OXYNTOMODULIN | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3086851 | — | EC50 | = | 0.17 | nM | 9.77 |
| CHEMBL3086852 | — | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL410972 | — | EC50 | = | 0.35 | nM | 9.46 |
| CHEMBL3086848 | — | Activity | - | — | - | |
| CHEMBL3086849 | — | Activity | - | — | - | |
| CHEMBL2401865 | OXYNTOMODULIN | Activity | - | — | - |