Compound Detail
CHEMBL3092448
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Basic Information
| ChEMBL ID | CHEMBL3092448 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FZBIFJDVJQDOQI-UHFFFAOYSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
331.3
MW (Da)
4.84
ALogP
2
HBA
0
HBD
14.2
PSA (Ų)
0.67
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelial lipase CHEMBL2380190 | IC50 | 7.51 | 7.51 | 31.0 | 3 |
| Endothelial lipase CHEMBL5080 | IC50 | 7.41 | 7.41 | 39.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelial lipase | IC50 | = | 31.0 | nM | 7.51 | Inhibition of mouse endothelial lipase using PLAi as substrate measured for 30 m... | 24900598 |
| Endothelial lipase | IC50 | = | 31.0 | nM | 7.51 | Endothelial Lipase Assay: To assay for cell surface lipase activity, cells expre... | - |
| Endothelial lipase | IC50 | = | 31.0 | nM | 7.51 | Inhibition of endothelial lipase in mouse cells after 30 mins by fluorescence as... | 29609119 |
| Endothelial lipase | IC50 | = | 39.0 | nM | 7.41 | Inhibition of human endothelial lipase using PLAi as substrate measured for 30 m... | 24900598 |
| Endothelial lipase | IC50 | = | 39.0 | nM | 7.41 | Endothelial Lipase Assay: To assay for cell surface lipase activity, cells expre... | - |
| Endothelial lipase | IC50 | = | 39.0 | nM | 7.41 | Inhibition of endothelial lipase in human cells after 30 mins by fluorescence as... | 29609119 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900598 | 10.1021/ml400361q | Endothelial lipase | 2 |
| 29609119 | 10.1016/j.ejmech.2018.03.061 | Endothelial lipase | 2 |
Data from ChEMBL 36 via Core Engine