Compound Detail
CHEMBL3092450
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3092450 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MXODNNNPSJJTNP-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
359.4
MW (Da)
5.40
ALogP
2
HBA
0
HBD
14.2
PSA (Ų)
0.61
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelial lipase CHEMBL5080 | IC50 | 7.85 | 7.85 | 14.0 | 2 |
| Endothelial lipase CHEMBL2380190 | IC50 | 7.77 | 7.77 | 17.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelial lipase | IC50 | = | 14.0 | nM | 7.85 | Inhibition of human endothelial lipase using PLAi as substrate measured for 30 m... | 24900598 |
| Endothelial lipase | IC50 | = | 14.0 | nM | 7.85 | Endothelial Lipase Assay: To assay for cell surface lipase activity, cells expre... | - |
| Endothelial lipase | IC50 | = | 17.0 | nM | 7.77 | Inhibition of mouse endothelial lipase using PLAi as substrate measured for 30 m... | 24900598 |
| Endothelial lipase | IC50 | = | 17.0 | nM | 7.77 | Endothelial Lipase Assay: To assay for cell surface lipase activity, cells expre... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900598 | 10.1021/ml400361q | Endothelial lipase | 2 |
Data from ChEMBL 36 via Core Engine