Compound Detail
CHEMBL309600
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Basic Information
| ChEMBL ID | CHEMBL309600 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LMKPPWNWUJXSAQ-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
226.3
MW (Da)
2.40
ALogP
2
HBA
1
HBD
37.9
PSA (Ų)
0.63
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL4124 | Ki | 8.64 | 8.64 | 2.3 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 2.3 | nM | 8.64 | In vitro antagonist potency at Histamine H3 receptor measured as K+-evoked [3H]h... | 9767653 |
| Histamine H3 receptor | Ki | = | 2.3 | nM | 8.64 | In vitro inhibitory activity against Histamine H3 receptor for K+ evoked depolar... | 11055360 |
| Histamine H3 receptor | Ki | = | 2.3 | nM | 8.64 | Effect on histamine H3 receptors in vitro, on synaptosomes of rat cerebral corte... | 11052804 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9767653 | 10.1021/jm9802970 | Histamine H3 receptor | 3 |
| 11055360 | 10.1016/s0960-894x(00)00473-x | Histamine H3 receptor | 2 |
| 11052804 | 10.1021/jm000966l | Histamine H3 receptor | 2 |
| 9767653 | 10.1021/jm9802970 | Histamine H2 receptor | 1 |
| 9767653 | 10.1021/jm9802970 | Histamine H1 receptor | 1 |
Data from ChEMBL 36 via Core Engine