Compound Detail
CHEMBL3109130
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Basic Information
| ChEMBL ID | CHEMBL3109130 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RJCXKCQDZMPEQQ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
293.3
MW (Da)
1.92
ALogP
6
HBA
0
HBD
64.0
PSA (Ų)
0.72
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 4.92 | 4.92 | 11920.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 11920.0 | nM | 4.92 | Inhibition of PI3Kalpha (unknown origin) after 1 hr by TR-FRET assay | 24345273 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24345273 | 10.1021/jm401138v | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1 |
| 24345273 | 10.1021/jm401138v | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
| 24345273 | 10.1021/jm401138v | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
Data from ChEMBL 36 via Core Engine