Compound Detail
CHEMBL3127264
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Basic Information
| ChEMBL ID | CHEMBL3127264 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FAYVDJDMYLGDEB-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
519.1
MW (Da)
5.60
ALogP
6
HBA
2
HBD
101.4
PSA (Ų)
0.27
QED
2
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Presequence protease, mitochondrial CHEMBL3124731 | EC50 | 7.92 | 6.9633 | 12.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Presequence protease, mitochondrial | EC50 | = | 12.0 | nM | 7.92 | Agonist activity at human PreP assessed as degradation of ATP synthase pF1beta s... | 24602793 |
| Presequence protease, mitochondrial | EC50 | = | 152.0 | nM | 6.82 | Agonist activity at human PreP assessed as degradation of fluorogenic substrate ... | 24602793 |
| Presequence protease, mitochondrial | EC50 | = | 713.0 | nM | 6.15 | Agonist activity at human PreP assessed as degradation of biotin-labeled amyloid... | 24602793 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24602793 | 10.1016/j.ejmech.2014.02.046 | Presequence protease, mitochondrial | 10 |
| 31610373 | 10.1016/j.ejmech.2019.111746 | Presequence protease, mitochondrial | 5 |
Data from ChEMBL 36 via Core Engine