Compound Detail
CHEMBL3133007
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O=C(Nc1ccc(O[C@H]2CC[C@@H](C(=O)O)CC2)nc1F)c1nnc(Nc2cc(F)c(F)cc2F)o1
Basic Information
| ChEMBL ID | CHEMBL3133007 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZGGVEUTUVCQEIJ-AOOOYVTPSA-N |
2
Targets
2
Activities
1
Assay Types
7
PK Parameters
7
Publications
0
Known Names
Molecular Properties
495.4
MW (Da)
4.04
ALogP
8
HBA
3
HBD
139.5
PSA (Ų)
0.25
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Diacylglycerol O-acyltransferase 1 CHEMBL6009 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Sterol O-acyltransferase 1 CHEMBL2782 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 200.0 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 4.6 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 300.0 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 1.8 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 2.0 | mL.min-1.g-1 | Homo sapiens |
| F | 61.0 | % | Canis lupus familiaris |
| F | 100.0 | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Diacylglycerol O-acyltransferase 1 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of human DGAT1 | - |
| Sterol O-acyltransferase 1 | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of human ACAT1 | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1039/C2MD20187A | Canis familiaris | 3 |
| - | 10.1039/C2MD20187A | Rattus norvegicus | 3 |
| - | 10.1039/C2MD20187A | No relevant target | 2 |
| - | 10.1039/C2MD20187A | Hepatocyte | 1 |
| - | 10.1039/C2MD20187A | MDCK | 1 |
| - | 10.1039/C2MD20187A | Sterol O-acyltransferase 1 | 1 |
| - | 10.1039/C2MD20187A | Diacylglycerol O-acyltransferase 1 | 1 |
Data from ChEMBL 36 via Core Engine