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Compound Detail

CHEMBL3133152

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CCN(CC)c1nc(NC2CCCC2)c2ncn([C@@H]3O[C@H](C(=O)NC)[C@@H](O)[C@H]3O)c2n1

Basic Information

ChEMBL ID CHEMBL3133152
Phase Preclinical
Structure Type MOL
InChI Key CBVUGFZCDWMPHK-QCUYGVNKSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

433.5
MW (Da)
0.39
ALogP
10
HBA
4
HBD
137.7
PSA (Ų)
0.49
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H31N7O4
MW 433.51
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness -0.15

Activity Summary

EC50 1 meas. best 5.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
EC50 5.6 5.6 2511.9 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Adenosine receptor A3 EC50 = 2511.89 nM 5.6 Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells ass... -

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C3MD00364G Unchecked 2
- 10.1039/C3MD00364G Adenosine receptors; A1 & A3 1
- 10.1039/C3MD00364G Adenosine receptor A2b 1
- 10.1039/C3MD00364G Adenosine receptor A2a 1
- 10.1039/C3MD00364G Adenosine receptor A1 1
- 10.1039/C3MD00364G Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine