Assay Detail
Functional
CHEMBL3135338
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human adenosine A3 receptor expressed in FlpIn-CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by fluorescence assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of N6-substituted 2-aminoadenosine-5-N-methylcarboxamides as A3 adenosine receptor agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 7.84 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | — | 1 | 9.30 |
| CHEMBL3133161 | — | — | 1 | 9.20 |
| CHEMBL3133078 | — | — | 1 | 8.80 |
| CHEMBL464859 | NECA | — | 1 | 8.50 |
| CHEMBL3133079 | — | — | 1 | 8.40 |
| CHEMBL3133080 | — | — | 1 | 8.30 |
| CHEMBL3133157 | — | — | 1 | 8.30 |
| CHEMBL3133153 | — | — | 1 | 8.30 |
| CHEMBL331372 | CGS-21680 | — | 1 | 8.00 |
| CHEMBL3133155 | — | — | 1 | 8.00 |
| CHEMBL3133154 | — | — | 1 | 8.00 |
| CHEMBL3133158 | — | — | 1 | 7.80 |
| CHEMBL3133160 | — | — | 1 | 7.50 |
| CHEMBL3133151 | — | — | 1 | 7.40 |
| CHEMBL3133156 | — | — | 1 | 7.40 |
| CHEMBL3133081 | — | — | 1 | 7.00 |
| CHEMBL3133159 | — | — | 1 | 6.90 |
| CHEMBL3133082 | — | — | 1 | 6.20 |
| CHEMBL3133152 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL3133161 | — | EC50 | = | 0.631 | nM | 9.20 |
| CHEMBL3133078 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL464859 | NECA | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL3133079 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3133080 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3133157 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3133153 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL331372 | CGS-21680 | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3133155 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3133154 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3133158 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3133160 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3133151 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3133156 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3133081 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3133159 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3133082 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3133152 | — | EC50 | = | 2511.89 | nM | 5.60 |