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Compound Detail

CHEMBL3133080

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CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCC(c4ccccc4)c4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL3133080
Phase Preclinical
Structure Type MOL
InChI Key REYVJXXPFHKIOC-CMCWBKRRSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

489.5
MW (Da)
1.02
ALogP
10
HBA
5
HBD
160.4
PSA (Ų)
0.26
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H27N7O4
MW 489.54
Aromatic Rings 4
Heavy Atoms 36
NP-Likeness 0.06

Activity Summary

EC50 4 meas. best 8.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
EC50 8.3 8.3 5.0 1
Adenosine receptor A2b
CHEMBL255
EC50 6.7 6.7 199.5 1
Adenosine receptor A1
CHEMBL226
EC50 6.4 6.4 398.1 1
Adenosine receptor A2a
CHEMBL251
EC50 6.1 6.1 794.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C3MD00364G Unchecked 2
- 10.1039/C3MD00364G Adenosine receptors; A1 & A3 1
- 10.1039/C3MD00364G Adenosine receptor A3 1
- 10.1039/C3MD00364G Adenosine receptor A2b 1
- 10.1039/C3MD00364G Adenosine receptor A1 1
- 10.1039/C3MD00364G Adenosine receptor A2a 1

Data from ChEMBL 36 via Core Engine