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Compound Detail

CHEMBL3133151

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CCNc1nc(NC2CCCC2)c2ncn([C@@H]3O[C@H](C(=O)NC)[C@@H](O)[C@H]3O)c2n1

Basic Information

ChEMBL ID CHEMBL3133151
Phase Preclinical
Structure Type MOL
InChI Key VCEGMGYGAGZEIK-PFHKOEEOSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

405.5
MW (Da)
-0.02
ALogP
10
HBA
5
HBD
146.4
PSA (Ų)
0.45
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H27N7O4
MW 405.46
Aromatic Rings 2
Heavy Atoms 29
NP-Likeness -0.02

Activity Summary

EC50 3 meas. best 7.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
EC50 7.4 7.4 39.8 1
Adenosine receptor A1
CHEMBL226
EC50 6.3 6.3 501.2 1
Adenosine receptor A2a
CHEMBL251
EC50 6.3 6.3 501.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C3MD00364G Unchecked 2
- 10.1039/C3MD00364G Adenosine receptor A2b 1
- 10.1039/C3MD00364G Adenosine receptors; A1 & A3 1
- 10.1039/C3MD00364G Adenosine receptor A3 1
- 10.1039/C3MD00364G Adenosine receptor A2a 1
- 10.1039/C3MD00364G Adenosine receptor A1 1

Data from ChEMBL 36 via Core Engine