Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL3133156

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CCCCNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C(=O)NC)[C@@H](O)[C@H]1O

Basic Information

ChEMBL ID CHEMBL3133156
Phase Preclinical
Structure Type MOL
InChI Key LWXHVFUOAMOHGI-AEISUSGSSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

365.4
MW (Da)
-1.01
ALogP
10
HBA
5
HBD
160.4
PSA (Ų)
0.40
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H23N7O4
MW 365.39
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness 0.10

Activity Summary

EC50 3 meas. best 7.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
EC50 7.4 7.4 39.8 1
Adenosine receptor A1
CHEMBL226
EC50 6.1 6.1 794.3 1
Adenosine receptor A2b
CHEMBL255
EC50 5.9 5.9 1258.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C3MD00364G Unchecked 2
- 10.1039/C3MD00364G Adenosine receptor A2a 1
- 10.1039/C3MD00364G Adenosine receptors; A1 & A3 1
- 10.1039/C3MD00364G Adenosine receptor A3 1
- 10.1039/C3MD00364G Adenosine receptor A1 1
- 10.1039/C3MD00364G Adenosine receptor A2b 1

Data from ChEMBL 36 via Core Engine