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Compound Detail

CHEMBL3133160

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CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)nc(N)nc32)[C@H](O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL3133160
Phase Preclinical
Structure Type MOL
InChI Key FZEBWDIAMQALDL-PFHKOEEOSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

399.4
MW (Da)
-0.61
ALogP
10
HBA
5
HBD
160.4
PSA (Ų)
0.38
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H21N7O4
MW 399.41
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -0.02

Activity Summary

EC50 4 meas. best 7.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
EC50 7.5 7.5 31.6 1
Adenosine receptor A2b
CHEMBL255
EC50 6.9 6.9 125.9 1
Adenosine receptor A2a
CHEMBL251
EC50 5.5 5.5 3162.3 1
Adenosine receptor A1
CHEMBL226
EC50 5.2 5.2 6309.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C3MD00364G Unchecked 2
- 10.1039/C3MD00364G Adenosine receptors; A1 & A3 1
- 10.1039/C3MD00364G Adenosine receptor A3 1
- 10.1039/C3MD00364G Adenosine receptor A2b 1
- 10.1039/C3MD00364G Adenosine receptor A2a 1
- 10.1039/C3MD00364G Adenosine receptor A1 1

Data from ChEMBL 36 via Core Engine