Compound Detail
CHEMBL314060
(R)-LOVIRIDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL314060 |
| Name | (R)-LOVIRIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FELUFXCUIYHAPB-MRXNPFEDSA-N |
1
Targets
7
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
440.1
MW (Da)
4.36
ALogP
3
HBA
2
HBD
72.2
PSA (Ų)
0.68
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 7 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 8.3 | 6.0286 | 5.0 | 7 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus 1 | EC50 | = | 5.0 | nM | 8.3 | Potency evaluated against wild type HIV-1 strain IIIB | 15115397 |
| Human immunodeficiency virus 1 | EC50 | = | 50.0 | nM | 7.3 | Potency evaluated against NNRTI-Resistant HIV-1 strain Leu100Ile | 15115397 |
| Human immunodeficiency virus 1 | EC50 | = | 1000.0 | nM | 6.0 | Potency evaluated against NNRTI-Resistant HIV-1 strain Val106Ala | 15115397 |
| Human immunodeficiency virus 1 | EC50 | = | 1260.0 | nM | 5.9 | Potency evaluated against NNRTI-Resistant HIV-1 strain Lys103Asn | 15115397 |
| Human immunodeficiency virus 1 | EC50 | = | 2510.0 | nM | 5.6 | Potency evaluated against NNRTI-Resistant HIV-1 strain Gly190Ala | 15115397 |
| Human immunodeficiency virus 1 | EC50 | = | 15800.0 | nM | 4.8 | Potency evaluated against NNRTI-Resistant HIV-1 strain Tyr181Cys | 15115397 |
| Human immunodeficiency virus 1 | EC50 | = | 50100.0 | nM | 4.3 | Potency evaluated against NNRTI-Resistant HIV-1 strain Tyr188Leu | 15115397 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15115397 | 10.1021/jm030558s | Human immunodeficiency virus 1 | 7 |
Data from ChEMBL 36 via Core Engine