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Compound Detail

CHEMBL315182

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C=C1/C(=C/C=C2/CCC[C@@]3(C)C2CCC3[C@H](C)C[C@H]2C[C@](C)(O)C(=O)N2C)C[C@@H](O)C[C@@H]1O

Basic Information

ChEMBL ID CHEMBL315182
Phase Preclinical
Structure Type MOL
InChI Key YCKBNQNSQUFGRQ-DARULXMRSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

457.7
MW (Da)
4.14
ALogP
4
HBA
3
HBD
81.0
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H43NO4
MW 457.66
Aromatic Rings 0
Heavy Atoms 33
NP-Likeness 2.27

Activity Summary

IC50 1 meas. best 7.99

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vitamin D3 receptor
CHEMBL2353
IC50 7.99 7.99 10.2 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Vitamin D3 receptor IC50 = 10.2 nM 7.99 In vitro relative binding affinity for chick intestinal vitamin D3 receptor comp... 15109656

Literature References

PubMed DOI Target Context # Activities
15109656 10.1016/s0960-894x(04)00294-x Vitamin D3 receptor 1
15109656 10.1016/s0960-894x(04)00294-x HL-60 1

Data from ChEMBL 36 via Core Engine