Assay Detail
Binding
CHEMBL820132
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In vitro relative binding affinity for chick intestinal vitamin D3 receptor compared to [3H]1
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of 1alpha,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1 alpha,25-dihydroxyvitamin D3 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.17 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431606 | — | — | 1 | 9.30 |
| CHEMBL314009 | — | — | 1 | 8.72 |
| CHEMBL315182 | — | — | 1 | 7.99 |
| CHEMBL2114211 | — | — | 1 | 7.52 |
| CHEMBL3350688 | — | — | 1 | 7.30 |
| CHEMBL3350292 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431606 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL314009 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL315182 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL2114211 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3350688 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3350292 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3350292 | — | IC50 | > | 100.0 | nM | - |