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Compound Detail

CHEMBL315670

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COc1cc([C@H]2Oc3cc(-c4oc5cc(O)cc(O)c5c(=O)c4O)ccc3O[C@@H]2CO)ccc1O

Basic Information

ChEMBL ID CHEMBL315670
Phase Preclinical
Structure Type MOL
InChI Key BVKQRAYKLBRNIK-HYBUGGRVSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

480.4
MW (Da)
3.16
ALogP
10
HBA
5
HBD
159.1
PSA (Ų)
0.29
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C25H20O10
MW 480.43
Aromatic Rings 4
Heavy Atoms 35
NP-Likeness 1.85

Activity Summary

IC50 1 meas. best 4.57
Ki 1 meas.

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
No relevant target
CHEMBL2362975
IC50 4.57 4.57 27000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
No relevant target IC50 = 27000.0 nM 4.57 Antioxidant activity assessed as DPPH radical scavenging activity after 10 mins 25442301

Literature References

PubMed DOI Target Context # Activities
26273725 10.1021/acs.jnatprod.5b00430 Staphylococcus aureus 4
11170636 10.1021/jm0004190 Staphylococcus aureus 1
25442301 10.1016/j.bmcl.2014.10.023 No relevant target 1
28042452 10.1039/C6MD00287K Solute carrier family 2, facilitated glucose transporter member 4 1

Data from ChEMBL 36 via Core Engine