Compound Detail
CHEMBL316892
8-HYDROXY QUINALDINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL316892 |
| Name | 8-HYDROXY QUINALDINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NBYLBWHHTUWMER-UHFFFAOYSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
159.2
MW (Da)
2.25
ALogP
2
HBA
1
HBD
33.1
PSA (Ų)
0.64
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Methionine aminopeptidase 2 CHEMBL3922 | IC50 | 5.69 | 5.69 | 2030.0 | 1 |
| Botulinum neurotoxin type A CHEMBL5192 | IC50 | 5.41 | 5.41 | 3900.0 | 1 |
| Human immunodeficiency virus type 1 integrase CHEMBL3471 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of Rickettsia prowazekii str. Madrid E N-terminal His-tagged methioni... | 28089350 |
| Methionine aminopeptidase 2 | IC50 | = | 2030.0 | nM | 5.69 | Inhibition of recombinant full length human N-terminal GST/His6-tagged methionin... | 28089350 |
| Botulinum neurotoxin type A | IC50 | = | 3900.0 | nM | 5.41 | Inhibition of protease activity of recombinant full length Clostridium botulinum... | 28043798 |
| Human immunodeficiency virus type 1 integrase | IC50 | = | 100000.0 | nM | 4.0 | Inhibition of HIV1 integrase 3' processing activity | 17452064 |
Literature References
Data from ChEMBL 36 via Core Engine