Compound Detail
CHEMBL3182733
PRAMIPEXOLE DIHYDROCHLORIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL3182733 |
| Name | PRAMIPEXOLE DIHYDROCHLORIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | APVQOOKHDZVJEX-QTPLPEIMSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL301265 |
| Active Moiety | CHEMBL301265 |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
16
Known Names
4
Indications
1
Mechanisms
Molecular Properties
211.3
MW (Da)
1.58
ALogP
4
HBA
2
HBD
50.9
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1997 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| D2-like dopamine receptor agonist | AGONIST | D2-like dopamine receptor | ✓ | ✓ |
Indications
Parkinson Disease Restless Legs Syndrome Bipolar Disorder Amyotrophic Lateral Sclerosis
Activity Summary
Ki 4 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(3) dopamine receptor CHEMBL234 | Ki | 9.3 | 9.3 | 0.5 | 1 |
| D(4) dopamine receptor CHEMBL219 | Ki | 8.89 | 8.89 | 1.3 | 1 |
| Unchecked CHEMBL612545 | Ki | 8.66 | 8.66 | 2.2 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 8.41 | 8.41 | 3.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor | Ki | = | 0.5 | nM | 9.3 | Binding affinity to human D3 receptor assessed as inhibition constant | 36758304 |
| D(4) dopamine receptor | Ki | = | 1.3 | nM | 8.89 | Binding affinity to human D4 receptor assessed as inhibition constant | 36758304 |
| Unchecked | Ki | = | 2.2 | nM | 8.66 | Binding affinity to human D2-like receptor assessed as inhibition constant | 36758304 |
| D(2) dopamine receptor | Ki | = | 3.9 | nM | 8.41 | Binding affinity to human D2 receptor assessed as inhibition constant | 36758304 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 36758304 | 10.1016/j.ejmech.2023.115172 | Unchecked | 1 |
| 36758304 | 10.1016/j.ejmech.2023.115172 | D(2) dopamine receptor | 1 |
| 36758304 | 10.1016/j.ejmech.2023.115172 | D(3) dopamine receptor | 1 |
| 36758304 | 10.1016/j.ejmech.2023.115172 | D(4) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine