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Compound Detail

CHEMBL3188193

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CCCCCCCCN1C(=O)[C@@H](CC(=O)NCc2ccc(OC)c(OC)c2)C[C@@]2(C(=O)OC)C1=C[C@H](C(C)C)O[C@@H]2C1CC1

Basic Information

ChEMBL ID CHEMBL3188193
Phase Preclinical
Structure Type MOL
InChI Key HMUQJRZTGCHCFQ-ZTDRBNPFSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

612.8
MW (Da)
5.80
ALogP
7
HBA
1
HBD
103.4
PSA (Ų)
0.19
QED
2
Ro5 Violations
16
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C35H52N2O7
MW 612.81
Aromatic Rings 1
Heavy Atoms 44
NP-Likeness 0.29

Activity Summary

IC50 1 meas. best 4.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 4.96 4.96 10849.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 10849.0 nM 4.96 PubChem BioAssay. QFRET-based biochemical high throughput dose response assay to... -

Data from ChEMBL 36 via Core Engine