Assay Detail
Binding
CHEMBL3214930
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PubChem BioAssay. QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10.. (Class of assay: confirmatory)
235
Total Activities
235
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Category | confirmatory |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 235 | 4.92 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.22 |
| CHEMBL1354188 | — | — | 1 | 5.33 |
| CHEMBL1371370 | — | — | 1 | 5.28 |
| CHEMBL1702515 | — | — | 1 | 5.27 |
| CHEMBL599255 | — | — | 1 | 5.26 |
| CHEMBL1504972 | — | — | 1 | 5.26 |
| CHEMBL1725768 | — | — | 1 | 5.23 |
| CHEMBL1717796 | — | — | 1 | 5.16 |
| CHEMBL1486739 | — | — | 1 | 5.14 |
| CHEMBL1341108 | — | — | 1 | 5.13 |
| CHEMBL1584720 | — | — | 1 | 5.13 |
| CHEMBL1877001 | — | — | 1 | 5.12 |
| CHEMBL1904601 | — | — | 1 | 5.11 |
| CHEMBL1321181 | — | — | 1 | 5.11 |
| CHEMBL2144898 | — | — | 1 | 5.09 |
| CHEMBL1898802 | — | — | 1 | 5.09 |
| CHEMBL1734361 | — | — | 1 | 5.08 |
| CHEMBL1543659 | — | — | 1 | 5.08 |
| CHEMBL1900400 | — | — | 1 | 5.07 |
| CHEMBL1374970 | — | — | 1 | 5.06 |
| CHEMBL1338847 | — | — | 1 | 5.06 |
| CHEMBL1414873 | — | — | 1 | 5.06 |
| CHEMBL1893620 | — | — | 1 | 5.05 |
| CHEMBL1377629 | — | — | 1 | 5.05 |
| CHEMBL1314100 | — | — | 1 | 5.04 |
| CHEMBL1891222 | — | — | 1 | 5.02 |
| CHEMBL1540477 | — | — | 1 | 5.02 |
| CHEMBL3183981 | — | — | 1 | 5.01 |
| CHEMBL1552655 | — | — | 1 | 5.01 |
| CHEMBL1372805 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | IC50 | = | 60.65 | nM | 7.22 |
| CHEMBL1354188 | — | IC50 | = | 4717.0 | nM | 5.33 |
| CHEMBL1371370 | — | IC50 | = | 5203.0 | nM | 5.28 |
| CHEMBL1702515 | — | IC50 | = | 5375.0 | nM | 5.27 |
| CHEMBL599255 | — | IC50 | = | 5532.0 | nM | 5.26 |
| CHEMBL1504972 | — | IC50 | = | 5438.0 | nM | 5.26 |
| CHEMBL1725768 | — | IC50 | = | 5929.0 | nM | 5.23 |
| CHEMBL1717796 | — | IC50 | = | 6926.0 | nM | 5.16 |
| CHEMBL1486739 | — | IC50 | = | 7234.0 | nM | 5.14 |
| CHEMBL1341108 | — | IC50 | = | 7426.0 | nM | 5.13 |
| CHEMBL1584720 | — | IC50 | = | 7454.0 | nM | 5.13 |
| CHEMBL1877001 | — | IC50 | = | 7587.0 | nM | 5.12 |
| CHEMBL1904601 | — | IC50 | = | 7855.0 | nM | 5.11 |
| CHEMBL1321181 | — | IC50 | = | 7694.0 | nM | 5.11 |
| CHEMBL1898802 | — | IC50 | = | 8030.0 | nM | 5.09 |
| CHEMBL2144898 | — | IC50 | = | 8138.0 | nM | 5.09 |
| CHEMBL1734361 | — | IC50 | = | 8354.0 | nM | 5.08 |
| CHEMBL1543659 | — | IC50 | = | 8389.0 | nM | 5.08 |
| CHEMBL1900400 | — | IC50 | = | 8484.0 | nM | 5.07 |
| CHEMBL1374970 | — | IC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL1414873 | — | IC50 | = | 8720.0 | nM | 5.06 |
| CHEMBL1338847 | — | IC50 | = | 8708.0 | nM | 5.06 |
| CHEMBL1377629 | — | IC50 | = | 8802.0 | nM | 5.05 |
| CHEMBL1893620 | — | IC50 | = | 8899.0 | nM | 5.05 |
| CHEMBL1314100 | — | IC50 | = | 9089.0 | nM | 5.04 |
| CHEMBL1891222 | — | IC50 | = | 9557.0 | nM | 5.02 |
| CHEMBL1540477 | — | IC50 | = | 9607.0 | nM | 5.02 |
| CHEMBL1552655 | — | IC50 | = | 9769.0 | nM | 5.01 |
| CHEMBL3183981 | — | IC50 | = | 9714.0 | nM | 5.01 |
| CHEMBL1372805 | — | IC50 | = | 10075.0 | nM | 5.00 |
| CHEMBL1880565 | — | IC50 | = | 10338.0 | nM | 4.99 |
| CHEMBL1867810 | — | IC50 | = | 10158.0 | nM | 4.99 |
| CHEMBL1313030 | — | IC50 | = | 10244.0 | nM | 4.99 |
| CHEMBL1581655 | — | IC50 | = | 10563.0 | nM | 4.98 |
| CHEMBL1870067 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1382277 | — | IC50 | = | 10569.0 | nM | 4.98 |
| CHEMBL1879258 | — | IC50 | = | 10504.0 | nM | 4.98 |
| CHEMBL3185562 | — | IC50 | = | 10607.0 | nM | 4.97 |
| CHEMBL3188193 | — | IC50 | = | 10849.0 | nM | 4.96 |
| CHEMBL1309498 | — | IC50 | = | 10902.0 | nM | 4.96 |
| CHEMBL1556968 | — | IC50 | = | 11027.0 | nM | 4.96 |
| CHEMBL1890686 | — | IC50 | = | 11243.0 | nM | 4.95 |
| CHEMBL2135228 | — | IC50 | = | 11331.0 | nM | 4.95 |
| CHEMBL1896572 | — | IC50 | = | 11320.0 | nM | 4.95 |
| CHEMBL1318620 | — | IC50 | = | 11401.0 | nM | 4.94 |
| CHEMBL1463761 | — | IC50 | = | 11726.0 | nM | 4.93 |
| CHEMBL1565496 | — | IC50 | = | 11688.0 | nM | 4.93 |
| CHEMBL1302531 | — | IC50 | = | 11653.0 | nM | 4.93 |
| CHEMBL1567029 | — | IC50 | = | 11770.0 | nM | 4.93 |
| CHEMBL1459330 | — | IC50 | = | 12040.0 | nM | 4.92 |