Compound Detail
CHEMBL320425
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CN1CCCC[C@@H](c2cccc(Oc3cc([C@](C)(N)c4cncn4C)ccc3C#N)c2)C1=O
Basic Information
| ChEMBL ID | CHEMBL320425 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DXJRWWRZZPRGJB-NVQXNPDNSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
443.6
MW (Da)
4.03
ALogP
6
HBA
1
HBD
97.2
PSA (Ų)
0.64
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| Geranylgeranyl transferase type I CHEMBL2095164 | IC50 | 7.04 | 7.04 | 92.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 11.0 | nM | 7.96 | Concentration required to inhibit recombinant human farnesyltransferase (FTase) ... | 12825937 |
| Geranylgeranyl transferase type I | IC50 | = | 92.0 | nM | 7.04 | Concentration required to inhibit recombinant human geranylgeranyl transferase t... | 12825937 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12825937 | 10.1021/jm020587n | Protein farnesyltransferase | 1 |
| 12825937 | 10.1021/jm020587n | Geranylgeranyl transferase type I | 1 |
Data from ChEMBL 36 via Core Engine