Compound Detail
CHEMBL32307
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Basic Information
| ChEMBL ID | CHEMBL32307 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FMKJUUQOYOHLTF-UPHRSURJSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
101.1
MW (Da)
-0.41
ALogP
2
HBA
2
HBD
63.3
PSA (Ų)
0.46
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 4.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit rho-2 CHEMBL2375 | EC50 | 4.16 | 4.16 | 70000.0 | 1 |
| Gamma-aminobutyric acid receptor subunit rho-1 CHEMBL3561 | EC50 | 4.13 | 4.13 | 74000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit rho-2 | EC50 | = | 70000.0 | nM | 4.16 | Partial agonist activity against human rho-2 subunit GABA-C receptor expressed i... | 10780899 |
| Gamma-aminobutyric acid receptor subunit rho-1 | EC50 | = | 74000.0 | nM | 4.13 | Partial agonist activity against human rho1 subunit GABA-C receptor expressed in... | 10780899 |
| Gamma-aminobutyric acid receptor subunit rho-1 | EC50 | = | 74000.0 | nM | 4.13 | Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes asses... | 18528996 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10780899 | 10.1021/jm9904349 | Gamma-aminobutyric acid receptor subunit rho-1 | 1 |
| 10780899 | 10.1021/jm9904349 | Gamma-aminobutyric acid receptor subunit rho-2 | 1 |
| 17655213 | 10.1021/jm070447j | Unchecked | 1 |
| 18528996 | 10.1021/jm7015842 | Gamma-aminobutyric acid receptor subunit rho-1 | 1 |
| 17417631 | 10.1038/nchembio873 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine