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Compound Detail

CHEMBL3233407

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CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccncc3)CC[C@@H]12

Basic Information

ChEMBL ID CHEMBL3233407
Phase Preclinical
Structure Type MOL
InChI Key GCOQAARUFVDXHC-PMACEKPBSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

376.5
MW (Da)
3.17
ALogP
5
HBA
0
HBD
39.7
PSA (Ų)
0.75
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H28N4O
MW 376.50
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -0.81

Activity Summary

Ki 3 meas. best 8.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 2A
CHEMBL224
Ki 8.33 8.33 4.7 1
Sodium-dependent serotonin transporter
CHEMBL228
Ki 7.0 7.0 101.0 1
5-hydroxytryptamine receptor 2C
CHEMBL225
Ki 5.96 5.96 1090.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24559051 10.1021/jm401958n 5-hydroxytryptamine receptor 2A 1
24559051 10.1021/jm401958n 5-hydroxytryptamine receptor 2C 1
24559051 10.1021/jm401958n D(2) dopamine receptor 1
24559051 10.1021/jm401958n Sodium-dependent serotonin transporter 1
24559051 10.1021/jm401958n Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine