Compound Detail
CHEMBL324389
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL324389 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HMVKGJOHYRCQRV-XNTDXEJSSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
271.3
MW (Da)
3.14
ALogP
5
HBA
2
HBD
87.8
PSA (Ų)
0.51
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitochondrial import inner membrane translocase subunit TIM10 CHEMBL1741194 | IC50 | 5.63 | 5.63 | 2320.0 | 1 |
| Mitochondrial import inner membrane translocase subunit TIM23 CHEMBL1741180 | IC50 | 5.29 | 5.29 | 5170.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitochondrial import inner membrane translocase subunit TIM10 | IC50 | = | 2320.0 | nM | 5.63 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
| Mitochondrial import inner membrane translocase subunit TIM23 | IC50 | = | 5170.0 | nM | 5.29 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14521417 | 10.1021/jm0301080 | Homo sapiens | 2 |
| 12419372 | 10.1016/s0960-894x(02)00725-4 | T-cell | 1 |
| 12419372 | 10.1016/s0960-894x(02)00725-4 | T-cell surface glycoprotein CD4 | 1 |
| 12419372 | 10.1016/s0960-894x(02)00725-4 | Unchecked | 1 |
| 12419372 | 10.1016/s0960-894x(02)00725-4 | Receptor-type tyrosine-protein phosphatase C | 1 |
| 14521417 | 10.1021/jm0301080 | NON-PROTEIN TARGET | 1 |
| 14521417 | 10.1021/jm0301080 | Colon carcinoma cell | 1 |
| 14521417 | 10.1021/jm0301080 | Melanoma tumor cell line | 1 |
Data from ChEMBL 36 via Core Engine