Compound Detail
CHEMBL3261328
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Basic Information
| ChEMBL ID | CHEMBL3261328 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | URNDNHCCRPRCLG-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
373.3
MW (Da)
3.98
ALogP
4
HBA
2
HBD
83.0
PSA (Ų)
0.83
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thyroid hormone receptor beta CHEMBL1947 | EC50 | 5.69 | 5.69 | 2040.0 | 1 |
| Thyroid hormone receptor alpha CHEMBL1860 | EC50 | 5.05 | 5.05 | 8880.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor beta | EC50 | = | 2040.0 | nM | 5.69 | Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed ... | 24712661 |
| Thyroid hormone receptor alpha | EC50 | = | 8880.0 | nM | 5.05 | Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed... | 24712661 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24712661 | 10.1021/jm4019299 | Thyroid hormone receptor beta | 2 |
| 24712661 | 10.1021/jm4019299 | Thyroid hormone receptor alpha | 2 |
| 24712661 | 10.1021/jm4019299 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine