Compound Detail
CHEMBL3261422
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Cc1cc(C)c(S(=O)(=O)NC(C)CS(=O)(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c(C)c1
Basic Information
| ChEMBL ID | CHEMBL3261422 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DVBJXHNYGBFVCK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
515.6
MW (Da)
4.23
ALogP
6
HBA
1
HBD
98.1
PSA (Ų)
0.40
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | IC50 | 6.1 | 6.1 | 795.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | IC50 | = | 795.0 | nM | 6.1 | Binding affinity to human glucocorticoid receptor by fluorescence polarization a... | 24755427 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24755427 | 10.1016/j.bmcl.2014.03.070 | Glucocorticoid receptor | 3 |
Data from ChEMBL 36 via Core Engine